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KMID : 0358319960370091003
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Korean Journal of Urology
1996 Volume.37 No. 9 p.1003 ~ p.1007
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The Effect of Intraurethral Instillation of PGE1, Solution in the Patients with Erectile Dysfunction
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Abstract
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Intracavernosal self injection therapy is now being widely used to treat patients with erectile dysfunction. However, there is a large number of patients who gives up the self injection program due to the fear of needle or injection. Therefore,
the
less
invasive route of drug administration is highly recommended. We investigated the efficacy of intraurethral instillation of PGE1 solution in comparison with the trimix intracavernosal injection. A total of 24 patients have been observed with
either
injection of trimix (11 patients), or intraurethral instillation of PGE1 (13 patients). All patients were evaluated with the penile doppler ultrasonography before 5,15,30 and 45 minutes after the drug administration. Penile length and
circumrerence
were
measured before and after intraurethral administration of PGE1. Ten out of 11 patients (91%) showed positive response in trimix group and nine of 13 patients (69.2%) in PGE1 group. Mean length and circumference of penile shaft before and after
the
pharmachologic erection test showed significant diffeerence in PGE1 group. The mean peak systolic veljocity at 30 minutes was 28.5±10.53 cm/sec in Trimix group and 28.2±8.47 cm/sec in PGE1 group (p=0.4773). The mean end diastolic velocity at 30
minutes was 8.4±5.23 cm/sec in Trimix group and 8.2±4.21 cm/sec in PGE1 group (p=0.4689). With the intraurethral administration of PGE1, urethral pain and irritation wer ethe noticeable complications but systemic side deffect was not noticed.
In conclusion, PGE1 intraurethral instillation can be satisfactorily use for the patients with erectile dysfunction of psycyhogenic, less prominent organic and neurogenic origin, although the effect of intraurethral instillation of PGE1 is
obviously
less than that of Trimix intracavernosal iniection.
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